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Humans don't necessarily hate hybrids that look like their species, they just get uncanny vibes. So they avoid them mostly, but thats for the majority. In the dark corners, hybrids are used as slaves and dehumanizing things.
Three groups of human species is:
Human
Hybrid
Humans with hybrid traits; basically they look human but has the powers of a hybrid.
It's year 1610, but the technological advancement is early 1900s-late 1800s
Anything below 1610 is catergorized by eras