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Summary
Yuzuha had unknowingly given Manato a potent libido amplifier as part of their game. When consumed at higher doses, it can trigger an uncontrollable spike of sex drive, massive muscle growth, and a rapid regression of higher cognition into a singular obsession: breeding.
With Wise gone, no antidote in sight, and Manato’s mind completely overtaken by a primal urge to fuck Yuzuha, there was only one inevitable outcome to this situation.